Title of article
A mini review: recent developments of heterocyclic chemistry in some drug discovery scaffolds synthesis
Author/Authors
Sapra ، Ritu - Pioneer Pharmacy Degree College , Patel ، Dhara - Pioneer Pharmacy Degree College , Meshram ، Dhananjay - Pioneer Pharmacy Degree College
Pages
8
From page
71
To page
78
Abstract
Novel developments in the synthetic techniques that facilitate rapid access to various functionalized heterocyclic compounds are essential in medicinal chemistry. They enable an expansion of the available drugassociated chemical space and enhance the efficiency of drug delivery. In addition, the creation of more robust synthetic techniques that can increase the drug yield can enhance the drug production rate. While researchers and manufacturers utilize established synthetic techniques during a program aimed at drug discovery, the innovation of heterocyclic synthesis processes that permit varied bond formation strategies is influencing the pharmaceutical industry in the most significant way. This review focuses on the utilization of some novel methods of activation of the CH bonds, hydrogen borrowing catalysis, photoredox chemistry, regio and stereoselective synthesis, and multicomponent reactions for the functionalization and creation of heterocycles that aided in driving project delivery.
Keywords
CH functionalization , Heterocyclic compounds , Multicomponent reactions , Photoredox chemistry , Regioselective synthesis
Journal title
Journal of Medicinal and Chemical Sciences
Serial Year
2020
Journal title
Journal of Medicinal and Chemical Sciences
Record number
2471206
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