The role of SiJunZi decoction in the management of gastric precancerous lesions and its mechanism

Gastric cancer remains one of the most common and aggressive malignant tumors worldwide. The occurence of gastric cancer experiences a cascade of multistep gastric carcinogenesis, starting from inflammation, metaplasia, and ultimately to dysplasia and carcinoma. Patients with gastric precancerous lesions, mainly including intestinal metaplasia and dysplasia, are more prone to suffer from gastric adenocarcinoma [1]. Therefore, early prevention and treatment regarding gastric precancerous lesions is an important way to reduce the risk of occurence of gastric cancer.