Title of article :
Fecal calprotectin Level in patients with IBD and noninflammatory disease of colon: a study in Babol, Northern, Iran
Author/Authors :
Sharbatdaran, Majid Cancer Research Center - Health Research Institute - Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran , Halakou, Amin Department of Pathology - Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran , Kashifard, Mehrdad Cancer Research Center - Health Research Institute - Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran , Bijani, Ali Social determinates Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran , Firozjaei, Alireza Cancer Research Center - Health Research Institute - Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran , Hossaini, Akram Cancer Research Center - Health Research Institute - Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran , Siadati, Sepideh Cancer Research Center - Health Research Institute - Faculty of Medicine - Babol University of Medical Sciences, Babol, Iran
Abstract :
Background: Inflammatory bowel disease (IBD) is a chronic disease with a relapsing
course of inflammation in the digestive system. Endoscopy and histopathology are the
golden standard methods for detection and assessment of IBD. A distinct increase of fecal
calprotectin level can be a useful marker for the diagnosis of IBD. The aim of this study
was to evaluate the fecal calprotectin level in patients with IBD and without inflammatory
diseases of the colon.
Methods: Calprotectin levels of patients referred to the Ayatollah Rouhani Hospital of
Babol, northern Iran with clinical symptoms of colon disease were evaluated. After a
week, colonoscopy and biopsy were performed on all patients and they were divided into
two groups. The first group included patients with confirmed IBD and the second group
included patients with diseases other than IBD, patients with IBS and healthy persons.
Then the measured fecal calprotectin level was compared between the two groups before
colonoscopy.
Results: We observed correlation between calprotection in these two groups (p<0.0001).
38 (86.8%) patients in the case group and 5 (13.2%) patients in the control group had
positive fecal calprotectin test and 12 (23.1%) patients in the case group and 40 (76.9%)
patients in the control group had negative results. Basad on ROC curve, the cutoff point of
calprotectin was 127.65 with 73% sensitivity and 89% specificity. The area under the
curve was 0.83 with 95% confidence interval, 0.74-0.91 (p<0.0001).
Conclusions: The results pointed to this fact that fecal calprotectin can be a noninvasive
marker in differentiating IBD from IBS.