Author/Authors :
Gharaei Nejad, Kaveh Skin Research Center - Department of Dermatology - Razi Hospital - Guilan University of Medical Sciences, Rasht, Iran , Eftekhari, Hojat Skin Research Center - Department of Dermatology - Razi Hospital - Guilan University of Medical Sciences, Rasht, Iran , Rafiei, Rana Skin Research Center - Department of Dermatology - Razi Hospital - Guilan University of Medical Sciences, Rasht, Iran , Darjani, Abbas Skin Research Center - Department of Dermatology - Razi Hospital - Guilan University of Medical Sciences, Rasht, Iran , Alizadeh, Narges Skin Research Center - Department of Dermatology - Razi Hospital - Guilan University of Medical Sciences, Rasht, Iran
Abstract :
Background: Darier disease (DD) is an autosomal dominant genetic disorder which develops from a mutation in the ATP2A2 gene. Inflammatory myopathies (IM) are the largest group of potentially treatable myopathies. In this case, we report development of IM in a patient with DD for the second time in the literature.
Case presentation: The patient is a 59-year-old female, a known case of DD, who developed proximal muscle weakness 2 weeks prior to admission. Elevated muscle-enzymes, as well as typical electromyographic and radiologic confirmed the diagnosis of IM. Conclusions: Abnormalities in intracellular calcium homeostasis may explain the association between DM and DD, therefore it is noteworthy to keep this association in mind and conduct more research regarding this issue.
Keywords :
Darier disease , Myositis , Dermatomyositis , Polymyositis
