Author/Authors :
Gholinezhad, Maryam Infertility and Reproductive Health Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, Iran , Gholsorkhtabaramiri, Masoumeh nfertility and Reproductive Health Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, Iran , Esmaeilzadeh, Sedigheh nfertility and Reproductive Health Research Center - Health Research Institute - Babol University of Medical Sciences, Babol, Iran , Ghanbarpour, Azita Clinical Research Development unit of Ayatollah Rouhani Hospital - Babol University of Medical Sciences, Babol, Iran
Abstract :
Background: Polycystic ovary syndrome (PCOs) is an endocrine-metabolic disorder. This study intends to determine the comparison of insulin resistance (IR) and metabolic disturbance in overweight/obese and normal-weight of young women with polycystic ovary syndrome. Methods: Using a comparative cross-sectional study design in 2015, 27 normal weight (183.15) vs. 8.3% (5) in the normal group (P<0.001). 82.4% (62) of the overweight/obese group revealed low insulin sensitivity (QUICKI<0.34) while this value was 17.6 % (13) within their lean counterparts (p<0.001). In the study group, 89.7 % (54) showed elevated fasting insulin concentration (>13μU/ml) vs. 10.3% (7) in the control group (p<0.001). Conclusions: Overweight/obese PCOs patients revealed higher insulin resistance and lower insulin sensitivity, and also greater TG and LDL cholesterol. Priority of management of insulin resistance and lipid profile should be considered on identifying these potentially major complications.
Keywords :
Insulin resistance , Obesity , Polycystic ovary syndrome , Overweight
