Author/Authors :
Vasheghani-Farahani, Ali Cardiac Primary Prevention Research Center (CPPRC) - Tehran Heart Center - Tehran University of Medical Sciences Tehran, Iran , Kazemnejad, Fatemeh Students' Scientific Research Center (SSRC) - Cardiac primary prevention Research Center - Tehran University of Medical Sciences, Tehran, Iran , Sadeghniiat-Haghighi, Khosro Baharloo Hospital - Tehran University of Medical Sciences, Tehran, Iran , Saadat, Soleil Sina trauma research center - Tehran University of Medical Sciences, Tehran, Iran , Tavakoli poor, Parya Obesity Research Center - Sina University Hospital - Tehran University of Medical Sciences, Tehran, Iran , Yazdani, Tahereh Obesity Research Center - Sina University Hospital - Tehran University of Medical Sciences, Tehran, Iran , Alidoosti, Mohammad Students' Scientific Research Center (SSRC) - Cardiac primary prevention Research Center - Tehran University of Medical Sciences, Tehran, Iran , Amooeian, Vahid Ghasem Students' Scientific Research Center (SSRC) - Cardiac primary prevention Research Center - Tehran University of Medical Sciences, Tehran, Iran , Ashraf, Haleh Cardiac Primary Prevention Research Center (CPPRC) - Tehran Heart Center - Tehran University of Medical Sciences Tehran, Iran
Abstract :
Background: It has been implicated that obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular disease including stroke, myocardial infarction, coronary artery disease (CAD) and hypertension. The aim of this study was to investigate the correlation between OSA and severity of atherosclerosis assessed by angiography. Methods: This study included 337 patients undergoing diagnostic coronary angiography at Tehran Heart Center, Iran. The Gensini score was obtained from each patient for coronary angiogram, and OSA were assessed by using Multivariable apnea prediction (MAP) risk index on the day of cardiac catheterization. The Gensini scores increased in accordance with increases in the MAP value.
Results: The prevalence rates of three-vessel disease were 68.0% in OSA group and 32.0% in non-OSA group. The MAP index was the most significant independent determinant for the Gensini score. Conclusions: The independent association between OSA and CAD, even after adjustment for traditional confounders, suggests that, OSA should be taken into account when considering risk factors for CAD.
Keywords :
Obstructive sleep apnea , Gensini score , Coronary artery disease , Coronary angiography , Atherosclerosis
