Antiapoptotic Effects of Interval and Continued Training and Crocin on the Muscle Tissue of the Rats with Type II Diabetes Induced by a Highfat Diet

Introduction: Diabetes is a metabolic disease, which is directly correlated with increased physical disabilities and muscle tissue damage. The present study aimed to investigate the antiapoptotic effects of interval and continued training and crocin on diabetic rats. Methods: In this study, 49 adult rats aged eight weeks with diabetes inducaed by a highfat diet and venous injection of streptozotocin were randomly assigned to seven groups, including highintensity interval training (HIIT), lowintensity continued training (LICT), HIIT with crocin consumption, LICT with crocin consumption, crocin consumption, sham, and control. The animals in the HIIT and LICT groups ran on a treadmill three sessions per week for eight weeks at the intensity of 8085% and 5055% of the maximum speed, respectively. The animals in the crocin consumption groups received 25 mg/kg of crocin weekly for eight weeks. Results: HIIT and LICT could significantly increase Bcl2 and decrease Bax and p53, as well as the ratio of Bax and Bcl2 (P≤0.05). In addition, crocin consumption could significantly increase Bcl2 and decrease Bax (P≤0.05). Training with crocin consumption had interactive effects on the increase of Bcl2 and decrease of p53 and ratio of Bax to Bcl2 (P≤0.05). Conclusion: According to the results, continued and interval training along with the consumption of crocin exerted interactive antiapoptotic effects on the rats with diabetes induced by a high fat diet.