Author/Authors :
MANSOURITORGABEH, H Medical Sciences School - Tarbiat Modares University , POURFATH ELAH, A.A Medical Sciences School - Tarbiat Modares University , MAHMOUDIAN SHOUSHTARI, M Iranian Blood Transfusion Organization Research Center, , REZAEI YAZDI, Z Mashhad Medical Sciences University , ESMAEILI, H Mashhad Medical Sciences University
Abstract :
Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII inhibitors and two patients had none. Because factor V and factor VIII share approximately 40% amino acid sequence homology in their A and C domains, it remains to be elucidated if it is one molecule that recognizes both factor V and VIII or whether there are two inhibitor molecules against common sites.
