Title of article :
I405V and -629C/A Polymorphisms of the Cholesteryl Ester Transfer Protein Gene in Patients with Coronary Artery Disease
Author/Authors :
Ghatreh Samani, Keihan Tabriz University of Medical Sciences , Noori, Mohamma Tabriz University of Medical Sciences , Rohbani Nobar, Mohammad Tabriz University of Medical Sciences , Hashemzadeh Chaleshtori, Morteza Shahrekord University of Medical Sciences , Farrokhi, Effat Shahrekord University of Medical Sciences , Darabi Ami, Masoud Shahrekord University of Medical Sciences
Pages :
6
From page :
103
To page :
108
Abstract :
Background: Cholesteryl ester transfer protein (CETP) plays a main role in high-density lipoprotein metabolism. CETP gene possesses several single nucleotide polymorphisms which have been associated with plasma high-density lipoprotein cholesterol (HDL-C) concentrations. The aim of this study was to determine the association of CETP -629C/A and I405V polymorphisms with coronary artery disease (CAD) in Iranian population. Methods: The presence of two CETP gene polymorphisms -629C/A and I405V were studied in 187 unrelated CAD cases and 136 controls. All the samples were clinically examined and lipid profile was estimated. Genotyping was performed using polymerase chain reaction/restriction fragment length polymorphism method. Results: The frequency of -629C/A and I405V allelic variants were found to be 0.732 and 0.366 in cases and 0.658 and 0.348 in controls, respectively. The frequency of A allele of -629C/A polymorphism in cases was significantly higher than that of controls. HDL-C in AA genotype was higher than CA and CC genotypes in controls. No significant effect of II, IV and VV genotypes was found in lipid profiles. Conclusion: No significant association was found between CETP I405V polymorphism and increased risk of CAD in Azeri population studied. AA genotype of -629C/A increased HDL but the risk of CAD in this genotype might be higher than CC genotype.
Keywords :
Cholesteryl ester transfer protein (CETP) gene , I405V , High-density lipoprotein (HDL) cholesterol , -629C/A
Journal title :
Astroparticle Physics
Serial Year :
2009
Record number :
2473360
Link To Document :
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