Title of article :
Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine
Author/Authors :
Jafarzadeh, Abdollah School of Public Health - Tehran University of Medical Sciences , Kardar, Golam A School of Public Health - Tehran University of Medical Sciences , Khoshnoodi, Jalal School of Public Health - Tehran University of Medical Sciences , Shokri, Fazel School of Public Health - Tehran University of Medical Sciences
Abstract :
A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder neonates. Our results indicate significantly decreased production of HBsAg-induced IL-12 in non-responder subjects compared to responders (P<0.01). Since IL-12 is produced mainly by antigen presenting cells (APC) and is considered to be crucial for initiation and polarization of CD4+ T-cell function, therefore, our findings could be interpreted to imply APC dysfunction in non-responder vaccinees
Keywords :
IL-12 , hepatitis B , vaccination , neonates
Journal title :
Astroparticle Physics
