Title of article
Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats
Author/Authors
Kumar Sinha, Rakesh Institute of Technology - Banaras Hindu University - Varanasi (India) , Kumar Ray, Amit Institute of Technology - Banaras Hindu University - Varanasi (India)
Pages
8
From page
119
To page
126
Abstract
Continuous four hours EEG (electroencephalogram) recordings and its power spectrum analysis using fast fourier transform (FFT) in urethane anesthetized male Charles Foster rats were performed in two groups: open brain injury and p-CPA (para-Chlorophenylalanine) pretreated before brain injury, respectively, and compared with the EEG power spectrum of control rats. The EEG power spectrum analysis showed that there was a faster recovery in p-CPA pretreated group than the injury group of rats. The results showed that the p-CPA (a 5-HT inhibitor) prevents pathological changes following brain injury. Simultaneously, the inference can also be drawn that EEG power spectrum analysis is a useful technique for monitoring the brain injury and its recovery following pharmacological treatments
Keywords
Brain injury , p-CPA , EEG power spectrum
Journal title
Astroparticle Physics
Serial Year
2003
Record number
2473885
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