Title of article :
Effect of p-CPA Pretreatment on EEG Power Spectra in Experimental Open Brain Injury in Rats
Author/Authors :
Kumar Sinha, Rakesh Institute of Technology - Banaras Hindu University - Varanasi (India) , Kumar Ray, Amit Institute of Technology - Banaras Hindu University - Varanasi (India)
Abstract :
Continuous four hours EEG (electroencephalogram) recordings and its power spectrum analysis using fast fourier transform (FFT) in urethane anesthetized male Charles Foster rats were performed in two groups: open brain injury and p-CPA (para-Chlorophenylalanine) pretreated before brain injury, respectively, and compared with the EEG power spectrum of control rats. The EEG power spectrum analysis showed that there was a faster recovery in p-CPA pretreated group than the injury group of rats. The results showed that the p-CPA (a 5-HT inhibitor) prevents pathological changes following brain injury. Simultaneously, the inference can also be drawn that EEG power spectrum analysis is a useful technique for monitoring the brain injury and its recovery following pharmacological treatments
Keywords :
Brain injury , p-CPA , EEG power spectrum
Journal title :
Astroparticle Physics
