Title of article
Flavonoids from the Aerial Parts of Artemisia biennis Willd
Author/Authors
Rostami Dehmoradkhani ، Kazhal - University of Yasouj , Jafari ، Azizollah - University of Yasouj , Shokoohinia ، Yalda - Kermanshah University of Medical Sciences , Emami ، Ahmad - Mashhad University of Medical Sciences , Mojarrab ، Mahdi - Kermanshah University of Medical Sciences
Pages
5
From page
364
To page
368
Abstract
Background: The current phytochemical study was carried out on a fraction of dried polar extract of aerial parts of Artemisia biennis Willd. which was previously reported to decrease the viability of the rat pheochromocytoma cell line PC12 in cell-based antioxidant assays. Methods: A combination of solid phase extraction (SPE) and high pressure liquid chromatography (HPLC) of the hydroethanolic extract was used to purify the compounds. Structures of the isolated compounds were elucidated by spectroscopic means, including 1H-NMR and MS analyses. Results: Three isolated and identified flavonoids in this study were luteolin, kaempferol and apigenin. Conclusion: The cytotoxic potential of flavone aglycones, as the major components of selected fraction in the hydroethanolic extract of A. biennis might partly be related to the high death rate of PC12 cells.
Keywords
Artemisia biennis , Luteolin , kaempferol , Apigenin , PC12 cell line
Journal title
Pharmaceutical Sciences
Serial Year
2019
Journal title
Pharmaceutical Sciences
Record number
2474229
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