Title of article
Immunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice
Author/Authors
Assmar, Mehdi Pasteur Institute of Iran , Hajizadeh Manjili, Masoud Razi vaccine and Serum Research Institute Of Iran , Esmaeili-Rastaghi, Ahmad R Pasteur Institute of Iran , Farahmand, Mahin Pasteur Institute of Iran , Piazak, Nourair Pasteur Institute of Iran , Rafati, Sima Pasteur Institute of Iran , Naddaf Dezfool, Saied R Pasteur Institute of Iran
Pages
5
From page
93
To page
97
Abstract
The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH
strain) was investigated. Immunized mice survived challenge infection and displayed increased
interferon gamma (INF-γ) production. On the other hand, nonimmunized controls died after 10 days
and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No
tachyzoites were detected in peritoneal exudates of the immunized mice 10 days after challenge. These
results indicate that the vaccination with γ-irradiated tachyzoites not only protects the mice against
challenge infection, but may circumvent the danger of the vaccine being life-threatening because of
remaining tachyzoites inside macrophages posing as a latent infection. I
Keywords
Gamma-irradiated tachyzoites , Toxoplasma gondii , immunization
Journal title
Astroparticle Physics
Serial Year
1999
Record number
2474268
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