Title of article :
Block of 5-HT2 Receptors Enhances Hippocampal Long-Term Potentiation
Author/Authors :
Naghdi, Nasser Dept. Of Physiology and Pharmacology - Pasteur Institute of Iran , Goodwin, Neveill Dept Of Physiology - University of Auckland - New Zealand , Pocket, Susan Dept Of Physiology - University of Auckland - New Zealand
Abstract :
The effect of endogenous serotonin on long-term potentiation (LTP) in region CAI was studied by blocking 5-HT2 receptors with ketanserin in rat hippocampal slices. Such a block significantly en-hanced long-term potentiation of the CAI population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. This implies that serotonin acts on 5-HT2 receptors in CAI to repress long-term potentiation.
Keywords :
Long-term potentiation , Synaptic plasticity , Serotonin , Hippocampus
Journal title :
Astroparticle Physics
