Title of article :
Expression of Galectins 1, 3 and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
Author/Authors :
Ayako Hossaka, Thais Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil , Ribeiro, Daniel A Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil , Focchi, Gustavo Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil , André, Sabine Faculty of Veterinary Medicine - Ludwig-Maximilians-University Munich - Munich, Germany , Fernandes, Mariana Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil , Cintra Lopes Carapeto, Fernando Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil , Souza Silva, Marcelo Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil , Oshima, Celina T F Department of Pathology - Federal University of São Paulo - UNIFESP, Brazil
Abstract :
Back ground: The aim of this study was to characterize the immunohistochemical expression
of galectin 1, 3, and 9 in normal oral epithelium, oral squamous papilloma, and oral squamous cell
carcinoma.
Materials and Methods: Immunohistochemical staining for galectins 1, 3, and 9 was evaluated
in 8 samples of normal oral squamous epithelium, 15 samples of oral squamous papilloma, and 41
samples of oral squamous cell carcinoma. Immunohistochemical data were assessed by Kruskal-
Wallis non-parametric test followed by Dunn’s test. For all analyzes, it was adopted the value of
P <0.05 for statistical signifi cance.
Results: Signifi cant differences were found in galectin- 3 expression when comparing ordinary
mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples.
Conclusion: These fi ndings indicate that galectin-3 is closely involved in malignant transformation
of oral mucosa cells.
Keywords :
Gale ctin-1 , galectin-3 , galectin-9 , oral squamous cell carcinoma , oral squamous papilloma
