Author/Authors :
Taheri Moghadam, Ghazaleh Student Research Committee - Hamadan University of Medical Sciences , Hosseini-Zijoud, Mostafa Clinical Research Development Unit - Imam Hossein Hospital - Shahid Beheshti University of Medical Sciences , Heidary Shayesteh, Tavakol Department of Toxicology and Pharmacology - School of Pharmacy - Hamadan University of Medical Sciences , Ghasemi, Hassan Student Research Committee - Hamadan University of Medical Sciences , Ranjbar, Akram Department of Toxicology and Pharmacology - School of Pharmacy - Hamadan University of Medical Sciences
Abstract :
Background: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i nduced oxidative stress in rat. Objectives: In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both. Materials and Methods: G roup one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress m arkers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant capacity (TAC) were measured. Results: Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered cisplatin -induced changes in TAC, TTG and LPO in blood. Conclusions: It is concluded that oxidative damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.
Keywords :
Propofol , Cisplatin , Oxibdative stress , Rat
