Title of article :
Design and Synthesis of New Imidazole Derivatives of Captopril
Author/Authors :
Houshdar Tehrani, Mohammad Hassan Department of Medicinal Chemistry - School of Pharmacy - Shaheed Beheshti University of Medical Sciences and Health Services, Tehran , Zarghi, Afshin Department of Medicinal Chemistry - School of Pharmacy - Shaheed Beheshti University of Medical Sciences and Health Services, Tehran , Erfani Jabarian, Laleh Department of Medicinal Chemistry - School of Pharmacy - Shaheed Beheshti University of Medical Sciences and Health Services, Tehran
Abstract :
A new series of alkylthio imidazole analogues of captopril, an ACE inhibitor used in the treatment of hypertension, was designed and synthesized in order to obtain agents more active than captopril with less side effects. All the compounds thus prepared were purified and characterized by IR, NMR and Mass analytical instruments.
Keywords :
ACE inhibitor , Synthesis , Captopril , Alkylthio imidazole derivatives
Journal title :
Astroparticle Physics
