Author/Authors :
Varela, María Morales Suárez Public and Environmental Health Unit - Department of Preventive Medicine - University of Valencia - CIBER Epidemiology and Public Health (CIBERESP) and Center for Public Health Research (CSISP), Valencia, Spain , Marcos, Luís García Pediatric Respiratory and Allergy Units - “Arrixaca” University Children’s Hospital - University of Murcia and CIBER of Epidemiology and Public Health (CIBERSP), Murcia, Spain , Espinar, Javier Fuertes Fernández Perpetuo Socorro” Health Center, Huesca, Spain , Sanz, Alberto Bercedo Meruelo Health Center, Santander, Spain , Ontoso, Inés Aguinaga Department of Health Sciences - Public University of Navarra, Pamplona, Spain , Díaz, Carlos González Department of Pediatrics - Basurto Hospital, Bilbao, Spain , Urueña, Ignacio Carvajal “La Ería” Health Center - Oviedo - Asturias Princedom Health Service, Asturias, Spain , Monge, Rosa María Busquet Department of Pediatrics - Hospital del Mar, Barcelona, Spain , Pena, Alberto Arnedo Centre of Public Health - Regional Health Authority, Castellón, Spain , de Andoin, Nagore García Department of Pediatrics - “Donostia” Hospital - San Sebastián, Guipuzcoa, Spain , Garrido, José Batlles Department of Pediatrics - “Torrecárdenas” Hospital, Almería, Spain , Quirós, Alfredo Blanco Department of Pediatrics - University of Valladolid, Spain , Silvarrey Varela, Ángel López María José Jove Foundation, La Coruña, Spain , Hernández, Gloria García- Pediatric Allergy and Pulmonology Unit - “12 de Octubre” University Children’s Hospital, Madrid, Spain , Clemente, Natalia Gimeno Public and Environmental Health Unit - Department of Preventive Medicine - University of Valencia - CIBER Epidemiology and Public Health (CIBERESP) and Center for Public Health Research (CSISP), Valencia, Spain , López, Nuria Rubio Public and Environmental Health Unit - Department of Preventive Medicine - University of Valencia - CIBER Epidemiology and Public Health (CIBERESP) and Center for Public Health Research (CSISP), Valencia, Spain , González, Agustín Llopis Public and Environmental Health Unit - Department of Preventive Medicine - University of Valencia - CIBER Epidemiology and Public Health (CIBERESP) and Center for Public Health Research (CSISP), Valencia, Spain
Abstract :
Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults,
and alters quality of life. Previous studies have suggested several socio-demographic and
environmental factors related to the prevalence of AE and other allergic diseases, including
acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with
asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the
level of association of these conditions with the use of acetaminophen. We analyzed Spanish data
from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the
Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma,
rhinitis and AE symptoms.
We observed an association between acetaminophen use and AE among the adolescents who
had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with
the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and
for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively.
We conclude that acetaminophen use in childhood may be an important factor associated
with development and/or maintenance of AE and other allergic diseases.
