Author/Authors :
Ghaffari, Javad Department of Allergy and Clinical Immunology - Molecular and Cellular Research Center - Faculty of Medicine - Mazandaran University of Medical Sciences - Sari, , Farid Hossaini, Reza Department of Allergy and Clinical Immunology - Faculty of Medicine - Mashhad University of Medical Sciences, Mashhad , Khalilian, Alireza Department of Biostatistics - Faculty of Health - Mazandaran University of Medical Sciences, Sari , Nahanmoghadam, Negin Department of General Pediatrics - Mazandaran University of Medical Sciences, Sari , Salehifar, Ebrahim Department of Pharmacology - Mazandaran University of Medical Sciences, Sari , Rafatpanah, Houshang Department of Immunology - Mashhad University of Medical Sciences, Mashhad
Abstract :
Asthma is the most common chronic inflammatory disorder characterized by cough,
wheezing and dyspnea in children. Nutrition is an important factor which influences on
induction and exacerbation of asthma. There are controversies to use Vitamin E in asthmatic
patients. The aim of this study was to evaluate the effect of vitamin E supplement in children
with moderate asthma.
This is a randomized double blind placebo-controlled trial performed on children (age 2-
17 years old) with moderate asthma (5-17 years old) from March 2010 to March 2012. Case
group were treated with fluticasone and vitamin E (50mg/day) and control group received
fluticasone plus placebo for 8 weeks.
Out of 300 cases, 240 cases completed the study. Female to male ratio was 0.84. Serum
level of Vitamin E significantly increased after treatment in intervention group. FEV1 and
FEV1/FVC ratio was significantly improved in case group compared to the control group.
It can be concluded that vitamin E supplement could improve clinical manifestations and
pulmonary function test in children with moderate asthma.
Keywords :
Asthma , Child , Dietory supplements , Respiratory function tests , Vitamins , Vitamin E
