Author/Authors :
Zahedifard, Sara Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Rashidi, Elahe Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Shams, Sedigheh Department of Pathology - Children Hospital Medical Center - Tehran University of Medical Sciences, Tehran , Saghafi, Shiva Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Fazlollahi, Mohammad Reza Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Talebzadeh, Azadeh Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran , Kazemnejad, Anoshirvan Department of Biostatistics - Tarbiat Modarres University, Tehran , Soltani, Ahmad Department of Cell and Molecular Biology - University of Tehran, Tehran , Pourpak, Zahra Immunology - Asthma and Allergy Research Institute - Tehran University of Medical Sciences, Tehran
Abstract :
Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two
critical functions: complement activation through the lectin pathway and opsonization. MBL
deficiency has been classified as the most common inherited immunodeficiency known in
humans (about 30% of the population), and is associated with predisposition to infections
and high risk of some autoimmune diseases. The purpose of this study was to determine the
profile of MBL serum level in Iranian healthy population in association with sex and age
groups for the first time.
We studied the serum concentration of MBL in 593 Iranian healthy cases: 340 males
and 235 females in 4 different age groups by using enzyme-linked immunosorbent assay.
The mean serum levels of MBL were 3.854± 2.770g/ml at the age of less than 6 months,
4.147±3.540g/ml at 6 months to 2 years of age, 4.410±3.090g/ml at 2-6 years and
2.207±1.730g/ml in adults. There was significant differences in the mean concentration of
MBL among different age groups of children and also between children and adults (p<0.05).
No association was observed between sex and MBL concentrations.
MBL serum levels of Iranian population seem to be different from some of other
populations which may be explained by genetic variations. The MBL values in this study can
be used as a normal reference range for future studies in Iranian population.
