Author/Authors :
Gheybi, Mohammad Kazzem The Persian Gulf Nuclear Medicine Research Centre - Bushehr University of Medical Sciences, Bushehr , Movahed, Ali Department of Biochemistry - Bushehr University of Medical Sciences, Bushehr , Dehdari, Reyhaneh The Persian Gulf Nuclear Medicine Research Centre - Bushehr University of Medical Sciences, Bushehr , Amiri, Shahram Department of Immunology, Asthma and Allergy - The Persian Gulf Tropical Medicine Research Center - Bushehr University of Medical Sciences, Bushehr , Khazaei, Hossein Ali Research Center for Cellular and Molecular - Department of Immunology and Hematology - Zahedan Medical Sciences University, Zahedan , Gooya, Mostafa Department of Immunology, Asthma and Allergy - The Persian Gulf Tropical Medicine Research Center - Bushehr University of Medical Sciences, Bushehr , Dehbashi, Fereshteh The Persian Gulf Nuclear Medicine Research Centre - Bushehr University of Medical Sciences, Bushehr , Fatemi, Atena Department of Immunology, Asthma and Allergy - The Persian Gulf Tropical Medicine Research Center - Bushehr University of Medical Sciences, Bushehr , Sovid, Neda The Persian Gulf Nuclear Medicine Research Centre - Bushehr University of Medical Sciences, Bushehr , Hajiani, Gholamreza Bushehr Blood Transfusion Organization (BBTO), Bushehr , Tahmasebi, Rahim Department of Biostatistics - School of Public Health - Bushehr University of Medical Sciences, Bushehr , Dobaradaran, Sina Department of Immunology, Asthma and Allergy - The Persian Gulf Tropical Medicine Research Center - Bushehr University of Medical Sciences, Bushehr , Assadi, Majid The Persian Gulf Nuclear Medicine Research Centre - Bushehr University of Medical Sciences, Bushehr , Farrokhi, Shokrollah The Persian Gulf Nuclear Medicine Research Centre - Bushehr University of Medical Sciences, Bushehr
Abstract :
Concerns have been raised about the adverse impact of dusty air pollution (DAP) on human health. The aim of this study was to find the association between dusty air pollution
based on air quality index (AQI) and the risk of allergic diseases in southwestern provinces of Iran, with assessing cytokine profiles and lymphocyte immunophenotypes.
In this case control study 148 individuals participated. The sampling was done in hazardous condition (AQI >300) as the case and clean air (AQI <50) as the control. We measured cytokine production by using ELISA method and phenotypes of T-lymphocytes (CD4+ and CD8+), CD19+ B-lymphocytes, CD25+, CD4+ CD25+ cells by FACSort flow
cytometer.
The mean serum level of IL-4 (33.4±2.9 vs 0.85± 0.65 pg/dl) and IL-13 (15.1±4.4 vs. 0.12±0.7 pg/dl) in the subjects exposed to ambient DAP was increased significantly
compared to the individuals in the clean air condition. Also, CD19+ B-lymphocytes (12.6± 4.9 vs 8.9±3.2%) and CD4+ CD25+ cell count (13.6± 4.6 vs 7.7± 3.8%) in peripheral blood were increased significantly in subjects exposed to ambient DAP compared with the
controls.
The result of our study suggested that ambient DAP affected immune system in a way that might lead to allergic diseases in the population.
