Author/Authors :
Mohammadi, Mojgan Physiology Research Center - Institute of Neuropharmacology - Kerman Universityof Medical Sciences, Kerman , Rastin, Maryam Department of Immunology - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Rafatpanah, Houshang Inflammation and Inflammatory Diseases Research Center - School of Medicine - Mashhad University of Medical sciences, Mashhad , Abdoli Sereshki, Haleh Physiology Research Center - Institute of Neuropharmacology - Kerman Universityof Medical Sciences, Kerman , Zahedi, Mohammad Javad Department of Gastroenterology - Afzalipour Hospital - Kerman University of Medical Sciences, Kerman , Nikpoor, Amin Reza Department of Immunology - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Baneshi, Mohammad Reza Modelling in Health Research Centre - Institute of Future Studies in Health - Kerman University of Medical Sciences, Kerman , Hayatbakhsh, Mohammad Mahdi Department of Gastroenterology - Afzalipour Hospital - Kerman University of Medical Sciences, Kerman
Abstract :
The association of HLA class II genes with ulcerative colitis (UC) as an autoimmune disease has been investigated for several years. However, factors responsible for genetic predisposition of this disease have so far not been clearly understood. In this study, for the first time, we aimed to investigate the association between HLA-DRB1 types and UC in the population of Kerman, a city southeast Iran.
HLA typing was performed among 85 UC patients and 95 healthy controls using PCR amplification, employing sequence specific primers (PCR-SSP). The DRB1 frequencies were determined in the patients and controls.
HLA-DRB1*04 was negatively associated with UC. Furthermore, HLA-DRB1*13 was significantly associated with severity of the disease (p=0.01) among UC patients.
This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.
Keywords :
HLA-DRB1 , IBD , Iran , PCR-SSP , Ulcerative colitis
