Oxamflatin Induces E-cadherin Expression in HeLa Cervical Carcinoma Cells

background: cervical cancer is currently among the most important causes of cancer-related deaths in women. the development of cervical cancer is associated with high-risk human papillomavirus (hpv) infections and a series of epigenetic changes in host cell genome, such as histone acetylation. furthermore, decreased e-cadherin level has been shown to play a critical role in cancer cell invasion and metastasis. oxamflatin has been reported to have anti-cancer efficacy. objectives:we aimed to study the effect of this drugoncervical cancer cell lines, hela cells, by assessing e-cadherin level as a marker of cancer invasion susceptibility. methods: hela cells were treated with oxamflatin, and total rna was obtained. then, quantitative real-time polymerase chain reaction (pcr) was performed to evaluate e-cadherin expression level in cells treated with oxamflatin. results: the findings of real-time pcr indicated that oxamflatin increased e-cadherin level in a time- and concentration-dependent manner. the level of e-cadherin significantly increased at the concentrations of 4mm(for 24 hours after treatment) and 2 and 4mm (for 48 hours after treatment) in comparison with corresponding control hela cells. conclusions: the present study proposed that oxamflatin may have anti-migratory and anti-invasive potential against cervical cancer cells, which should be further evaluated in future studies.