Author/Authors :
Jahangiri, Alireza Department of Medicinal Chemistry - Pharmaceutical Sciences Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran , Mahmoudian, Masoud Department of Pharmacology - Faculty of Medicine - Iran University of Medical Sciences, Tehran , Jalalizadeh, Hassan Department of Medicinal Chemistry - Pharmaceutical Sciences Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran , Shafiee, Abbas Department of Medicinal Chemistry - Pharmaceutical Sciences Research Center - Faculty of Pharmacy - Tehran University of Medical Sciences, Tehran
Abstract :
There are many evidences that human serum paraoxonase activity modifies plasma lipid profile and paraoxonase has an antiatherogenic property. Non-selective beta-blockers affect plasma lipid profile too, but they have atherogenic property when patients take these drugs in long term. In this study the effect of propranolol, a non-selective beta-blocker, on paraoxonase activity was investigated. Lineweaver-Burk and secondary plots were drawn and showed that propranolol is a mixed non-competitive inhibitor of paraoxonase.
