Author/Authors :
Kalantar, Enayatollah Dietary Supplements and Probiotics Research Center - Alborz University of Medical Sciences, Karaj, Iran , Gharavi, Mohammad Javad Department of Microbiology and Immunology - School of Paramedical Sciences - Iran University of Medical Sciences, Tehran, Iran , Ghaffari Hoseini, Shervin Infectious Diseases and Tropical Medicine Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Heshmat, Ramin Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Oshaghi, Mojgan Dietary Supplements and Probiotics Research Center - Alborz University of Medical Sciences, Karaj, Iran , Gharegozlou, Behnaz Dietary Supplements and Probiotics Research Center - Alborz University of Medical Sciences, Karaj, Iran , Asayesh, Hamid Department of Medical Emergencies - Qom University of Medical Sciences, Qom, Iran , Mahdavi Gorabi, Armita Chronic Diseases Research Center - Endocrinology and Metabolism Population Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Motlagh, Mohammad Department of Pediatrics - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Esmaeil Noroozi, Mehdi Social Determinants of Health Research Center - University of Social Welfare and Rehabilitation Sciences, Tehran, Iran , Qorbani, Mostafa Non-communicable Diseases Research Center - Alborz University of Medical Sciences, Karaj, Iran & Endocrinology and Metabolism Research Center - Endocrinology and Metabolism Clinical Sciences Institute - Tehran University of Medical Sciences, Tehran, Iran , Kelishadi, Roya Department of Pediatrics - Child Growth and Development Research Center - Research Institute for Primordial Prevention of Non-communicable Disease - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national school-based surveillance system in Iran, entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease (CASPIAN) study. Detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. Trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. Fasting venous blood was examined for fasting blood sugar and lipid profile. Results: Overall 882 serum samples were suitable for testing. H. pylori antibody was found in 643 serum samples (72.9%). Among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in H. pylori positive and 42.8±11.3 in H. pylori negative group; p=0.04). Overall, 5.1% of adolescents with positive H. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). In the multivariate regression model, H. pylori seropositivity increased the risk of overweight (OR, 3.3; 95%CI, 1.2-9.3; p= 0.03). In the multivariate model, association of other cardiometabolic risk factors with H. pylori infection was not statistically significant (p>0.05). Conclusion: Results of present study showed that H. pylori infection was associated with excess weight in adolescents. H. pylori eradication may be decrease the risk of obesity.
