Author/Authors :
Jafarpour, Masoud Department of Radiology and Medical Physics- Faculty of Paramedicine- Kashan University of Medical Sciences, Kashan , Salimian, Morteza Department of Medical laboratory- Faculty of Paramedicine- Kashan University of Medical Sciences, Kashan , Mohseni, Mehran Department of Radiology and Medical Physics- Faculty of Paramedicine- Kashan University of Medical Sciences, Kashan , Talari, Hamid Reza Department of Radiology- Kashan University of Medical Sciences, Kashan , Aliasgharzadeh, Akbar Department of Radiology and Medical Physics- Faculty of Paramedicine- Kashan University of Medical Sciences, Kashan , Farhood, Bagher Department of Radiology and Medical Physics- Faculty of Paramedicine- Kashan University of Medical Sciences, Kashan , Moradi, Habiballah Department of Radiology and Medical Physics- Faculty of Paramedicine- Kashan University of Medical Sciences, Kashan , Safari, Hossein Health Promotion Research Center- Iran University of Medical Sciences, Tehran
Abstract :
Computed tomography (CT) is one of the most important diagnostic X-ray procedures which plays an important role
in increasing the patient dose values. The purpose of this clinical study was to evaluate the efficacy of vitamins E
and C in lowering down the level of DNA double strand break (DSB) caused by CT scan. Sixty patients for
abdomen/pelvic enhanced CT scan were randomly assigned to placebo (control), vitamin C, and vitamin E groups.
The patient blood samples were taken before and immediately after the CT scan. Counting the number of DSB was
performed using γ-H2AX method as a sensitive biomarker. Immediately after the CT scan, the mean number of
DSBs/cell increased in all three groups of control (131%, P<0.001), vitamin C (103%, P <0.001), and vitamin E
(66%, P<0.001) compared to their mean before the CT scan. Furthermore, the results showed that vitamin E
decreased the mean number of DSBs/cell by 22% in comparison with the control group (P =0.023), whereas vitamin
C had no significant effect on reducing the DSB (<3%, P =0.741). It is concluded that the administration of vitamin
E one hour before the CT scan, significantly decreases DSB levels.
Keywords :
Computed tomography (CT) , DNA double strand break (DSB) , Vitamin C , Vitamin E
