• Title of article

    Association of pityriasis rosea with Human Herpesvirus-6

  • Author/Authors

    Banihashemi, Mahnaz Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Javidi, Zari Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Khani, Fatemeh Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad , Ghiasi-Moghadam, Taghi Department of Pathology - Mashhad University of Medical Sciences, Mashhad , Ghaffarzadegan, Kamran Department of Pathology - Mashhad University of Medical Sciences, Mashhad , Hashemzadeh, Sara Cutaneous Leishmaniasis Research Center - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad

  • Pages
    4
  • From page
    122
  • To page
    125
  • Abstract
    Background: Pityriasis rosea (PR) is a common papulosquamous skin disorder that is suspected to have an infectious etiology. We aimed to study the role of human herpesvirus-6 (HHV-6) in the pathogenesis of PR. Method: We used immunohistochemical (IHC) assays to detect HHV-6 in patients with PR. Fifty-one patients with PR and 35 age and sex matched healthy control samples were enrolled in the study. The intensity and percentage of cell staining for HHV-6 infection were evaluated and recorded. Result: The intensity of IHC staining was negative in 25 (49.01%) patients and 24 (68.58%) control samples while it was +1 in 6 (11.77%) patients and 11 (31.42%) control samples, +2 in 4 (7.85%) patients and +3 in 16 (31.37%) of them. The incidence of moderate and intense staining for HHV-6 was significantly higher among patients with PR than the control group (P value < 0.01). Conclusion: We concluded that HHV-6 infection may play a role in some patients with PR. The rate of HHV-6 infection was significantly higher in PR patients than the control group.
  • Keywords
    human herpes virus-6 (HHV-6) , immunohistochemistry , pityriasis rosea
  • Journal title
    Astroparticle Physics
  • Serial Year
    2014
  • Record number

    2480517

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2480517