Abstract :
thrombotic disorders, such as myocardial
infarction, ischemic stroke, peripheral arterial
disease, deep venous thrombosis, pulmonary
embolism, or other embolic diseases that are responsible
for worldwide mortality and morbidity, are manifestations
of the formed thrombi by blood clots during a pathologic
blood coagulation process. Once thrombi are formed, the
only way to resolve the blood clot is treatment with
specific thrombolytic agents, so called plasminogen
activators (PAs), such as tissue-PAs (tPAs), urokinase,
and streptokinase (SK). PAs convert the endogenous
human plasminogen (HPG: the inactive proenzyme) to
plasmin (HPM: the active enzyme), which cleaves the
fibrin network of the blood clot, a process known as
fibrinolysis
Keywords :
Streptokinase , Treatment , Thrombotic Disorders , the End of the Beginning
