Title of article :
Frequency of autoimmune diseases in first degree relatives of psoriatic patients compared with controls: A cross-sectional study
Author/Authors :
Dastgheib, Ladan Molecular Dermatology Research Center - Shiraz University of Medical Sciences, Shiraz , Saki, Nasrin Molecular Dermatology Research Center - Shiraz University of Medical Sciences, Shiraz , Heiran, Alireza Student Research Committee - Shiraz University of Medical Sciences, Shiraz , Kardeh, Bahareh Student Research Committee - Shiraz University of Medical Sciences, Shiraz , Saki, Mohammad Reza Student Research Committee - Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Psoriasis is a chronic autoimmune skin disorder
with relapsing erythematous scaling plaques and joint or nail
involvement. A greater occurrence of other autoimmune diseases
has been reported in these patients. Additionally, their family
members are more likely to be diagnosed with psoriasis. The aim
of this study is to assess the prevalence of certain autoimmune
diseases in first degree relatives of patients with psoriasis
compared with a control group.
Methods: In this cross-sectional study we used a questionnaire
to compare the frequency of type 1 diabetes, autoimmune
thyroid disease, vitiligo, lupus erythematosus, multiple sclerosis,
ulcerative colitis, Crohn’s disease, and rheumatoid arthritis in
first degree relatives of 109 pathologically confirmed psoriasis
cases with the first degree relatives of 109 age-sex matched
controls. R programming language (version 3.3.1 for Windows)
and the rattle graphical user interface (GUI) package were applied
for statistical analysis. A P-value≤0.05 was considered to be
statistically significant.
Results: We compared 955 first degree relatives of psoriatic
patients with 934 family members of the controls. There was
significantly greater total autoimmune diseases [odds ratio
(OR): 2.74, 95% confidence interval (CI): 1.95-3.87, P<0.001),
particularly psoriasis (OR: 38.66, 95% CI: 5.3-282.19, P<.0001),
in first degree relatives of psoriatic patients compared to family
members of the control group. Regardless of gender, autoimmune
thyroid disease was more prevalent among first degree relatives
of psoriatic patients (OR: 2.81, 95% CI: 1.36-5.83, P=.0066). No
statistically significant difference was found regarding type 1
diabetes, rheumatoid arthritis, multiple sclerosis, vitiligo, Crohn’s
disease, and ulcerative colitis.
Conclusion: First degree relatives of patients with psoriasis
had significantly higher autoimmune diseases. This finding was
particularly noticed for psoriasis and autoimmune thyroid disease.
Keywords :
frequency , autoimmunity , familial , psoriasis , epidemiology
Journal title :
Astroparticle Physics
