Author/Authors :
Tavakkoly Bazzaz, Javad Department of Medical Genetics - School of Medicine - Tehran University of Medical Sciences - Tehran, Iran , Darbeheshti, Farzaneh Department of Medical Genetics - School of Medicine - Tehran University of Medical Sciences - Tehran, Iran , Izadi, Pantea Department of Medical Genetics - School of Medicine - Tehran University of Medical Sciences - Tehran, Iran , Emami Razavi, Amir Nader Iran National Tumor Bank - Cancer Institute of Iran - Tehran University of Medical Sciences - Tehran, Iran , Yekaninejad, Mir Saeed Department of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences - Tehran, Iran
Abstract :
Previous studies have suggested that BRCA1 dysregulation has been shown to have a role in triplenegative
phenotypic manifestation. However, differences of BRCA1 expression, as a tumor suppressor gene, have
rarely been investigated between luminal and triple-negative breast tumors. Therefore, the present
study attempted to compare the BRCA1 expression in triple-negative with luminal breast tumors and its
association with the clinicopathologic characteristics of patients. Methods: BRCA1 expression was evaluated by
real-time PCR in 26 triple-negative and 27 luminal breast tumors. Results: The results revealed that there is a high
frequency of BRCA1 underexpression in both triple-negative and luminal breast tumors. The BRCA1
underexpression was related to young age at diagnosis, lymph node involvement, and grade ІІІ tumors.
Conclusion: The observations suggest that decreased BRCA1 expression, regardless of tumor subtype, has a
general role in breast malignancy and associated with poor prognostic features in breast tumors.
