Author/Authors :
Pirouzi, Saeid Department of Dermatology - Azad University, Tehran , Zargari, Omid Skin Research Cente - Shahid Beheshti University of Medical Sciences,Tehran , Kamyab, Kambiz Department of Pathology - Tehran University of Medical Sciences, Tehran , Kesty, Katarina Wake Forest University School of Medicine, Winston-Salem, NC, USA
Abstract :
Perforating necrobiosis lipoidica (PNL) is a very rare variant
of necrobiosis lipoidica (NL), almost always associated with
diabetes. A non-diabetic 43-year-old man referred to us with
a gradually enlarging plaque on his forehead. The patient
was initially diagnosed with cutaneous tuberculosis based on
the histopathologic findings, but failed to respond to antituberculosis
therapy. Upon further evaluation and observation
of the transepidermal elimination of degenerated collagen in the
pathology slides, we rendered a diagnosis of PNL. The patient
underwent successful treatment with topical tacrolimus and
systemic hydroxychloroquine.
