Author/Authors :
PRAKASH, Jai Dept. Physiology - King George’s Medical University, Lucknow, India , MITTAL, Balraj Dept. of Genetics - Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India , AWASTHI, Shally Dept. of Pediatrics - King George’s Medical University, Lucknow, India , SRIVASTAVA, Neena Dept. Physiology - King George’s Medical University, Lucknow, India
Abstract :
Background: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes.
Methods: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method.
Results: The −243A>G polymorphism of the GAD-2 gene was significantly associated with higher risk of obesity (P<0.05).
Conclusion: GAD-2 gene polymorphisms influence obesity and related phenotype in complex manner, probably by regulating the food intake, insulin and body weight.
Keywords :
Obesity , Insulin , GAD-2 , Food intake , Polymorphism
