Feasibility of Biological Monitoring of Anatomy Laboratory Staff Exposed to Formaldehyde

Background: Formaldehyde (FA) is a reactive carcinogenic compound and is used routinely in anatomy theatres. Recently, biological monitoring is introduced as a method of choice for monitoring of exposed workers to hazardous chemicals with systemic absorption. Objectives: Considering the toxicity of formaldehyde and lack of a comprehensive method for its biological monitoring, the aim of this study was to explore a new and non-invasive method for biological monitoring of formaldehyde exposure in the staffs of anatomy theatre. Methods: This study was a cross-sectional investigation and the population of this study was comprised of 20 exposed staffs in an anatomy theatre in Tehran, Iran. The personal monitoring of 20 staff was carried out during the early winter, according to a method from the National Institute of Occupational Safety and Health No. 2016. Biological monitoring was conducted by measuring FA in staff’s exhaled breath after termination of the work shift. The data obtained were statistically analyzed using correlation analysis. Results: The mean FA personal exposure and its concentration in the exhaled breath of anatomy’s staffs were 698 34 and 195 17 as ppb, respectively. Correlation of staff’s personal exposures to formaldehyde with the excreted formaldehyde in their exhaled breath was statistically significant (P < 0.001). Conclusions: The present study showed that the personal exposure of staffs to the FA was higher than the permissible exposure limit. Statistically significant positive correlation of staff exposure with the content of FA in their exhaled breath indicated the potential of biological monitoring of exposed group to FA through exhaled breath.