Estimation of the Change of Ovarian Cancer Incidence in Kazakhstan: Component Analysis of Its Dynamics with the Consideration of Ethnic Features

Background: We examined epidemiological aspects of dynamic changes in incidence of ovarian cancer in women of Kazakh and Russian nationalities in Kazakhstan. Methods: The material of investigation was primary data on registered patients with malignant ovarian tumors in the whole country. The study was conducted during the period of 1999-2009. Evaluation of changes in ovarian cancer incidence in the female population of Kazakhstan was performed using component analysis. Results: The number of patients with ovarian cancer in the whole country is increasing. This increase is due to several major reasons, including population growth (all females – ΔP=+22.1%, females of Kazakh nationality – ΔP=+46.0% and females of Russian nationality – ΔP=−259.3%), changes in the age structure (all females – ΔA=+32.7%, females of Kazakh nationality – ΔA=+27.1 and females of Russian nationality – ΔA=+130.8),and changes in risks of developing the disease (all females – ΔR=+36.0%, females of Kazakh nationality – ΔR=+13.1% and females of Russian nationality – ΔR=+246.8%). Conclusion: This investigation was the first epidemiological study of dynamics of ovarian cancer by component anal-ysis in women of Kazakh and Russian nationalities in Kazakhstan. Implementation of the results of the study is rec-ommended in management of anti-cancer activities for ovarian cancer.