Title of article :
The Association between GSTM1, GSTT1 Genetic Variants and Gastric Carcinoma Susceptibility in Chinese: A Systematic Review Article
Author/Authors :
YOU, Dingyun Dept. of Science and Technology - Kunming Medical University, Kunming, China , LU, Nanjia Zhejiang Provincial Key Laboratory of Pathophysiology - School of Medicine - Ningbo University, Ningbo, China , DUAN, Donghui Zhejiang Provincial Key Laboratory of Pathophysiology - School of Medicine - Ningbo University, Ningbo, China , LI, Hui Institute of Non-Communicable Disease Control and Prevention - Ningbo Municipal Center for Disease Control and Prevention, Ningbo , China , XING, Wenhua Zhejiang Provincial Key Laboratory of Pathophysiology - School of Medicine - Ningbo University, Ningbo, China
Abstract :
Background: Glutathione S-transferases (GSTs) have been investigated as potential carcinoma susceptible genes. However, the relationship between GSTs (GSTM1, GSTT1) variants and gastric carcinoma (GC) risk has been con-troversial in Chinese population.
Methods: A comprehensive literature search strategy (PubMed, Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wan fang Database, etc.) was launched. Crude odds ratios (ORs) and confidence intervals (95% CI) were applied to estimate the strength of the association.
Results: Significant associations between GSTs genetic polymorphisms and GC were evidenced under random-effects model (ORGSTM1=1.56, 95% CI: 1.39 to 1.76, I2=50.7%, P<0.0001; ORGSTT1=1.24, 95% CI: 1.10 to 1.39, I2=43.6%, P=0.014; ORGSTM1-GSTT1=1.51, 95% CI: 1.26 to 1.81, I2=59.7%, P=0.004). The pooled ORs were not quali-tatively changed when any single study was omitted by sensitivity analysis.
Conclusion: Our results indicated an increased GC risk in Chinese population with GSTM1 and GSTT1 null geno-type and GSTM1-GSTT1 dual null genotype. Further multi-center
Keywords :
GSTM1 , GSTT1 , Chinese , Gastric Carcinoma
Journal title :
Astroparticle Physics
