Author/Authors :
NAGHIBZADEH-TAHAMI, Ahmad Physiology Research Center - Institute of Neuropharmacology - Kerman University of Medical Sciences, Kerman , YAZDI FEYZABADI, Vahid Health Services Management Research Center - Institute for Futures Studies in Health - Kerman University of Medical Sciences, Kerman , KHANJANI, Narges Monash Center for Occupational and Environmental Health - School of Public Health and Preventive Medicine - Monash University, Melbourne, Australia , ASHRAFI-ASGARABAD, Ahad Dept. of Epidemiology - Bam University of Medical Sciences - Kerman, Iran Social Determinants of Health Research Center - Institute for Futures Studies in Health - Kerman University of Medical Sciences, Kerman , ALIZAEH, Hosniyeh Iranian Research Center on Aging - University of Social Welfare and Rehabilitation Sciences, Tehran , BORHANI-NEJAD, Reza Cancer Research Center - Shahid Beheshti University of Medical Sciences, Tehran , MORADI-JOO, Mohammad Medical Informatics Research Center - Institute for Futures Studies in Health - Kerman University of Medical Sciences, Kerman , ZEINALI, Masoud Gastroenterology and Hepatology Research Center - Institute of Neuropharmacology - Kerman University of Medical Sciences, Kerman , ZAHEDI, Mohammad Javad Endocrinology and Metabolism Research Center - Institute of Neuropharmacology - Kerman University of Medical Sciences, Kerman , AGHAEE-AFSHAR, Mahmoud Research Center for Modeling in Health - Institute for Futures Studies in Health - Kerman University of Medical Sciences, Kerman , HAGHDOOST, Ali Akbar Research Center for Modeling in Health - Institute for Futures Studies in Health - Kerman University of Medical Sciences, Kerman
Abstract :
Background: Colorectal cancers (CRCs) including colon, rectum and anal cancers are the third most prevalent can-cers in the world. There are strong evidence showing the risk of the cigarette smoking, alcohol use, low physical activi-ty and some types of diets in CRCs; however, few studies explored the relationship between opium use and CRCs. This study aimed to investigate the association between opioid use and the incidence of CRCs.
Methods: In a population-based matched case-control study in Kerman, Iran, 175 patients with colorectal cancers and 350 healthy controls (matched for age, sex, and place of residence) were interviewed from Sep 2014 to Nov 2014. Opium and its derivatives, cigarette, alcohol, and diet use were collected using a valid and reliable questionnaire. Con-ditional logistic regression was used to estimate odds ratios with 95% confidence intervals.
Results: The use of opioids was associated with an increased risk of CRCs (adjusted odds ratio= 4. 5, 95% CI: 2. 4-8. 7). In addition, a dose-response relationship was observed between the cumulative use of opioids and the incidence of CRCs (with low use OR=3. 7; 95% CI: 1. 5-8. 6 and high use OR= 8. 0; 95% CI: 2. 9-21. 7). This dose-response rela-tionship was also strong in patients with colon cancers, with OR= 3. 9 (95% CI: 1. 5-9. 9) and 9. 4 (95% CI: 3. 3-27. 0) for the low and high uses of opioids, respectively.
Conclusion: Opioid use can lead to an increased risk of CRCs. Therefore, it is necessary to implement preventive policies to control the use of opioids.
Keywords :
Risk factor , Colorectal cancers , Opioid , Case-control , Iran
