Title of article
Synthesis and Antimicrobial Activity of Some New Isatin Derivatives
Author/Authors
Patel, Ankur Department of Medicinal Chemistry - R.C. Patel College of Pharmacy, India , Bari, Sanjay Department of Medicinal Chemistry - R.C. Patel College of Pharmacy, India , Talele, Gokul Department of Medicinal Chemistry - R.C. Patel College of Pharmacy, India , Patel, Jitendra Department of Medicinal Chemistry - R.C. Patel College of Pharmacy, India , Sarangapani, Manda bUniversity College of Pharmaceutical Sciences - Kakatiya University, India
Pages
6
From page
249
To page
254
Abstract
Some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-H-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (VIII) have been synthesized from different isatinhydrazones (II) by condensing with 2-phenyl-5-benzylidene- 3-N (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (VII). Their chemical structures have been confirmed by IR, 1HNMR, MASS and by elemental analysis. Investigation of antimicrobial activity of compounds was done by the disk diffusion technique. Among the compounds tested, the compound with 5-Br substitution showed the most favourable antimicrobial activity.
Keywords
Isatin , Isatin hydrazone , Imidazolone , Antibacterial , Antifungal
Journal title
Astroparticle Physics
Serial Year
2006
Record number
2481249
Link To Document