Author/Authors :
Gupta, Malaya Department of Pharmaceutical Technology - Jadavpur University, India , K.anti Mazumder, Upal Department of Pharmaceutical Technology - Jadavpur University, India , Haldar, Pallab K. Gupta College of Technological Sciences, India , Kandar, Chandi C. Department of Pharmaceutical Technology - Jadavpur University, India , Manikandan, Laxmanan Department of Pharmaceutical Technology - Jadavpur University, India , Senthil, G. P. Department of Pharmaceutical Technology - Jadavpur University, India
Abstract :
The methanolic extracts of Indigofera aspalathoides (MEIA) and Wedelia calendulaceae (MEWC) were evaluated for their anticancer activity against Ehrlich Ascites Carcinoma (EAC) in Swiss albino mice. On day 1, the extract of Indigofera aspalathoides at a dose of 250 and 500 mg/kg body weight and the extract of Wedelia calendulaceae at a dose of 250 and 500 mg/kg body weight were administered orally and continued for 9 consecutive days. The anticancer activity of MEIA and MEWC were examined by determining the tumor volume, tumor cell count, viable tumor cell count, nonviable tumor cell count, mean survival time and increase in life span in experimental animal models. Both these extracts increased the life span of EAC treated mice and restored the hematological parameters as compared with the EAC bearing mice. Thus, the present study revealed that the MEIA and MEWC showed anticancer activity in the tested animal models.
Keywords :
Indigofera aspalathoides , Wedelia calendulaceae , Ehrlich acitic carcinoma , Anticancer
