Author/Authors :
Dhawan, Indrani Dept. of Pathology - Vardhman Mahavir Medical College & Safdarjung Hospital - New Delhi, India , Rawal, Gireesha Dept. of Pathology - Vardhman Mahavir Medical College & Safdarjung Hospital - New Delhi, India , Kumar Yadav, Amit Dept. of Pathology - Vardhman Mahavir Medical College & Safdarjung Hospital - New Delhi, India , Zaheer, Sufian Dept. of Pathology - Vardhman Mahavir Medical College & Safdarjung Hospital - New Delhi, India
Abstract :
Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue
sarcomas in adults. Distant metastases are developed in 30–40% of patients with
MFH, with the most common site being the lung. However, metachronous MFH has
not been reported previously in literature. This report describes a case of a 30-yearold
man, who had two metachronous thigh tumors, both of which were confirmed to
be MFH on histopathology and immunohistochemistry evaluations. A contemporary
multidisciplinary approach to therapy including surgery, radiation and chemotherapy
was advocated. Two primary sites of MFH raised the possibility of a genetic abnormality
that could predispose such a patient to develop multiple primary sites of the
same tumor.
