Comparison of Elevated Liver Enzymes in Type 2 Diabetic Patients in User and Non-User of Statin

Background Type-2 diabetes is a risk factor for progressive non-alcoholic fatty liver disease and the majority of diabetic patients have blood lipid disorders, so they take statin drugs. Statins have the adverse effects such as liver dysfunction and increase in liver enzymes. The purpose of this study was to compare the liver enzymes in type 2 diabetic patients who are user and non-user of statin. Materials and Methods In a case-control study, increased liver enzymes (ALT and AST > 40 U/L) were measured in blood samples of 200 type II diabetic patients (with and without statin consumption) who referred to Mashhad Diabetes Clinic in Mashhad city (Iran), during May to November 2017. Levels of liver enzymes and anthropometric indices were measured for both groups. Liver enzymes were assessed at the baseline of two groups. The SPSS 20th software was used for data analysis. Results The mean of Body mass index in two groups of diabetic patients with and without statin consumption had a significant difference (p <0.05). The mean of ALP in both groups was not statistically significant, but the mean of LDL, ALT, AST and cholesterol levels in two groups of patients was statistically significant (p<0.05). Conclusion Based on the results, cholesterol level in diabetic patients with statin consumption was higher than non-consuming group.