Author/Authors :
SABOORI, Somayeh Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , DJALALI, Mahmoud Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , YOUSEFI RAD, Esmaeil Nutritional Health Research Center - Lorestan University of Medical Sciences, Khorramabad , Nematipour, Ebrahim Dept. of Cardiology - Tehran Heart Center - Tehran University of Medical Sciences, Tehran , SABOOR-YARAGHI, Ali Akbar Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , JAVANBAKHT, Mohammad Hassan Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran , ESHRAGHIAN, Mohammad Reza Dept. of Biostatistics - School of Public Health - Tehran University of Medical Sciences, Tehran , RAMEZANI, Atena Dept. of Basic Sciences and Nutrition - Cardiovascular Research Center - School of Public Health - Mazandaran University of Medical Sciences, Sari , KOOHDANI, Fariba Dept. of Cellular and Molecular Nutrition - School of Nutritional Sciences and Dietetics - Tehran University of Medical Sciences, Tehran
Abstract :
Background: Omega 3 and vitamin E are two critical nutrients which include beneficial effects in coronary artery disease (CAD). The aim of this study was to assess the effects of omega 3 alone supplementation or in combination with vitamin E on serum glucose and lipid levels and insulin resistance in CAD patients.
Methods: Participants of this clinical trial included 60 male patients with CAD who selected from Tehran Heart Cen-ter in Tehran, Iran in 2014. They received 4 g/day omega 3 plus 400 IU/day vitamin E (OE), 4 g/day omega 3 with vitamin E placebo (OP), or omega 3 and vitamin E placebo (PP) for two months. Serum glucose, lipids and insulin were assessed and HOMA-IR was calculated before and after the trial and effects of these nutrients on the highlighted parameters were compared within the study groups.
Results: Serum glucose level increased significantly in OP group (P=0.004), but not in OE group. OE and OP groups showed a significant decrease in fasting serum TG (P=0.020 and P=0.001, respectively). Serum insulin and HOMA-IR decreased significantly in OE group (P=0.044 and P=0.039, respectively) but did not change significantly in OP group.
Conclusion: Although, omega 3 supplementation may include adverse effects on serum glucose level, co-administration of omega 3 and vitamin E can beneficially decrease serum insulin and insulin resistance in CAD pa-tients.
Keywords :
CAD , Omega 3 , Vitamin E , Glucose homeostasis , Insulin resistance
