Author/Authors :
Sadeghpour, Hossein Department of Medicinal Chemistry - School of Pharmacy - Shiraz University of Medical Sciences, Shiraz , Ghasemi, Yones Pharmaceutical Sciences Resaerch Center and Department of Biotechnology - School of Pharmacy - Shiraz University of Medical Sciences, Shiraz , Rezaie, Zahra Department of Medicinal Chemistry - School of Pharmacy - Shiraz University of Medical Sciences, Shiraz , Khabnadideh, Soghra Department of Medicinal Chemistry - School of Pharmacy - Shiraz University of Medical Sciences, Shiraz , Falahzadeh, Zahra Pharmaceutical Sciences Resaerch Center - Shiraz University of Medical Sciences
Abstract :
We have previously synthesized new N-alkylated azoles (1b-7b) as antifungal
agents. Here, we evaluated the antibacterial activities of these compounds against
two gram positive and two gram negative bacteria by broth microdilution method.
The aminothiazole derivative (7b) showed an excellent antibacterial activity. Other
compounds exhibited moderate to good antibacterial activity. All compounds are more
active against gram positive than against gram negative bacteria.
Keywords :
Aminothiazole , Antibacterial , Benzimidazole , Benzotriazole
