Title of article :
The Anti-Angiogenic Activity of Phoenix Dactylifera Seeds Methanol Extract in Vivo Study
Author/Authors :
Hussein, Zeena A Department of Pharmacy - Al-Rasheed University College - Baghdad, Iraq , Al-Zubaidy, Adeeb A Pharmacology Department - College of Pharmacy - Al-Nahrain University - Baghdad, Iraq , Sahib, Hayder B Pharmacology Department - College of Pharmacy - Al-Nahrain University - Baghdad, Iraq
Abstract :
The aim of the study was to identify the antiangiogenic activity of Phoenix dactylifera seeds methanolic
extract in vivo and the probable anti-angiogenic mechanism of action. The date seeds were extracted with
methanol using cold method, the crude extract was tested on chick chorioallantoic membrane (CAM) as an in
vivo anti-angiogenic assay. Fourier transform infrared spectroscopy FT-IR was carried to identify the functional
group for the active chemical constituents. The results demonstrated significant inhibition of blood vessels
growth, and FTIR showed the presence of different functional group such as OH, NH2 and phenols. From the
data above the mechanism of action may relate to the presence of flavonoids and other phenolic compounds, as
they have direct perturbing action on blood vessels and prevent cell proliferation of endothelial cells growth via
their potent antioxidant and anti-inflammatory effects
Keywords :
natural compounds , CAM assay FT-IR , angiogenesis Phoenix dactylifera , vascular endothelial growth factor , in vivo study , phenolic compounds , antioxidant
Journal title :
Astroparticle Physics
