Author/Authors :
Ahad, Hindustan Abdul Department of Pharmaceutics - College of pharmacy - Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, INDIA , Kumar, Chitta Suresh Department of Pharmaceutics - College of pharmacy - Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, INDIA , CM, Anuradha Department of Pharmaceutics - College of pharmacy - Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, INDIA , Reddy, Kishore Kumar Department of Pharmaceutics - College of pharmacy - Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, INDIA , Sekhar A, Chandra Department of Pharmaceutics - College of pharmacy - Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, INDIA
Abstract :
The present study was performed to explore the matrix property of Ficus
glomerata fruit mucilage for making transdermal patches. The mucilage was
evaluated for its physicochemical properties. Various transdermal patches of
indomethacin were prepared by solvent evaporation technique using different
proportions of F. glomerata fruit mucilage. The compatibility studies between
indomethacin and F. glomerata fruit mucilage revealed that there were no negative
interactions between indomethacin and the mucilage. The formulated patches were
evaluated for physical properties, pre-formulary, post-formulary and skin irritation
characteristics and they were found satisfactory. The experimental results shows that
the drug release from the patches delayed in controlled manner as the proportion
of F. glomerata fruit mucilage increased. The accelerated stability studies proved
that the formulated patches were stable at stressed storage conditions. It was
concluded that F. glomerata fruit mucilage can be used as polymer for making
transdermal patches.
