Title of article
The Effects of Topical Sildenafil on Wound Healing in Rat
Author/Authors
Jamshidzadeh, Akram Department of Pharmacology and Toxicology and Pharmaceutical Research Center - Faculty of Pharmacy - Shiraz University of Medical Sciences , Azarpira, Negar Transplant Research Center - Nemazi Hospital - Shiraz University of Medical Sciences
Pages
6
From page
43
To page
48
Abstract
Nitric oxide (NO) is an important molecule synthesized during wound repair.
Studies have reported the use of NO donors on cutaneous wound repair, but their
effects in different phases of healing are not elucidated. The aim of this work was
to investigate the effects of topical sildenafil on wounds in rats. Sildenafil (25 mg)
was topically applied once daily on wound in treatment groups. On days, 7, 14 and
21 of lesion, five animals in each group were randomly selected and sacrificed and
histological properties were evaluated. Our results showed the wound area contracted
to 15% of the original size by day 7 post-wounding in treated group. Whereas control
rats showed significantly delayed wound healing. The wound area contracted to 26%
of the original size by day 14 post-wounding and to 46% by day 21 post-wounding.
Also sildenafil cream caused more fibroblast and macrophage migration, increased
vascularization, collagen regeneration, and epithelialization. This study indicates that
sildenafil cream augments the wound healing process and may be of clinical benefit.
Keywords
Nitric oxide , Sildenafil cream , Wound healing
Journal title
Astroparticle Physics
Serial Year
2011
Record number
2481896
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