Author/Authors :
Jain, Akansha SAFE Institute of Pharmacy - Indore - M.P., India , Jain, Shubham SAFE Institute of Pharmacy - Indore - M.P., India , Panwar, Aakash S. College of Pharmacy - IPS Academy - Indore - M.P., India , Jain, Ankit College of Pharmacy - IPS Academy - Indore - M.P., India , Sharma, Praveen College of Pharmacy - IPS Academy - Indore - M.P., India , Darwhekar, G. N. College of Pharmacy - IPS Academy - Indore - M.P., India
Abstract :
The effect of prepared Ayurvedic formulation was evaluated on excision and
incision wound models in rats. The wound-healing activity was assessed by the rate
of period of epithelialization and skin-breaking strength. Histological study of the
granulation tissue was carried out to know the extent of collagen formation in the
wound tissue. The Ayurvedic formulation prepared was then promoted for woundhealing
activity in two wound models. The treated animals showed a significant
reduction in the wound area and faster rate of epithialisation. In an incision wound
model, formulation treated animals demonstrated a significant skin-breaking
strength. Histological studies of the tissue obtained from the formulation treated group
revealed that the activity was more significant in this group. Our present study reveals
that the Ayurvedic formulation posses a potent wound healing activity, which could
be a good choice of remedy for wound healing but less potent than standard
nitrofurazone.
