Title of article :
Poly (Lactic-co-Glycolic) Acid (PLGA)-Based Compounds for Articular Cartilage Regeneration
Author/Authors :
Tavakoli, Ebrahim Department of Biomedical Engineering - Faculty of Engineering, University of Isfahan , Mehdikhani-Nahrkhalaji, Mehdi Department of Biomedical Engineering - Faculty of Engineering, University of Isfahan , Sarafbidabad, Mohsen Department of Biomedical Engineering - Faculty of Engineering, University of Isfahan
Abstract :
The most famous artificial polymers for cartilage regeneration constructs are
poly lactic acid (PLA, which is present in both L and D forms), poly-glycolic
acid (PGA), and their copolymer poly-lactic-co-glycolic acid (PLGA). PLGA
shows high biocompatibility, a potential to break down into safe monomer
units, a beneficial range of mechanical characteristics, and governable
degradation time depending on the copolymer ratio. In this review we
critically focused on PLGA applications such as scaffolds and carriers for
bioactive agents such as drugs, growth factors, and other bioactive molecules
in order to safely delivering to cartilage tissue for reconstructing articular
cartilage (AC) defects.
Keywords :
Articular Cartilage Regeneration , Degradation , Biocompatibility , Scaffold , Drug Carrier Tissue Engineering , PLGA
Journal title :
Astroparticle Physics
