Author/Authors :
Mirzaei, Hamidreza Cancer Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Sabetrasekh, Parisa Cancer Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Sabetrasekh, Parto Cancer Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Parvin, Mahmoud Department of Pathology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Torbati, Peyman Department of Pathology - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hajian, Parastoo Radiation Oncology - Shohadaye Tajrish Hospital, Tehran, Iran
Abstract :
Background: Tumor growth, invasion, and metastasis are angiogenesis dependent; so, using anti-angiogenic therapies can block
these procedures. Vascular endothelial growth factor (VEGF) is a strong proangiogenic factor that is expressed by many cancer cells
like bladder cancer.
Objectives: The aim of this study was to determine the prevalence of the VEGFR in transitional cell carcinoma (TCC) of bladder and
its relationship with other prognostic factors.
Methods: This cross sectional study was carried out on 61 patients with TCC of bladder after radical cystectomy (RC). These patients
were referred to the UrologyWard in Labbafineazhad Hospital in Tehran, Iran. The relationship of VEGF and the prognostic factors
was determined, using the Fisher’s Exact and Chi-square for data analyzing by SPSS software version 17.
Results: Among 61 patients with TCC of bladder, only 8 patients (13.1%) were VEGFR positive, and there was no significant relation
between frequency of VEGFR expression and the other factors like age, gender, stage, lymph node involvement, lymphovascular, or
perineural space invasion.
Conclusions: According to this study, the most patients with TCC of bladder did not express VEGFR; also, none of the prognostic
factors showed any relation with VEGFR expression.
