Title of article :
Antisense Non-Coding RNA in the INK4 Locus (ANRIL) in Human Cancers
Author/Authors :
Taheri, Mohammad Urogenital Stem Cell Research Center - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Ghafouri-Fard, Soudeh Department of Medical Genetics - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Context: ANRIL (antisense non-coding RNA in the INK4 locus) is one of the oncogenic long non-coding RNAs (lncRNAs), which is
located at the 9p21.3. It has a regulatory epigenetic function on its neighboring gene cluster p15/CDKN2B-p16/CDKN2A-p14/ARF. Such
regulatory role has led to contribution of ANRIL in the pathogenesis of many human cancers.
Evidence Acquisition: We searched the PubMed, Google Scholar, EMBASE, andWeb of Science databases till February 2018 with the
key words "ANRIL" or "antisense non-coding RNA in the INK4 locus" and "cancer" or "tumor" or "malignancy".
Results: ANRIL over-expression is documented in several cancers. The underlying mechanism for regulatory effect of ANRIL on the
expression of its neighboring tumor suppressors has been clarified in some malignancies. Moreover, ANRIL over-expression has
been associated with cisplatin and 5-fluorouracil (5-FU)-resistance in some cancers.
Conclusions: ANRIL is regarded as a potential biomarker in diverse cancer types and a therapeutic target in certain malignancies.
Keywords :
Cancer , ANRIL , lncRNA
Journal title :
Astroparticle Physics
