Title of article :
Synthesis of Two Novel 3-Amino-5-[4-chloro-2-phenoxyphenyl]-4H-1,2,4-triazoles with Anticonvulsant Activity
Author/Authors :
Mahdavi, Mohammad Department of Medicinal Chemistry - Faculty of Pharmacy and Drug Design & Development Research Center - Tehran University of Medical Sciences , Akbarzadeh, Tahmineh Department of Medicinal Chemistry - Faculty of Pharmacy and Drug Design & Development Research Center - Tehran University of Medical Sciences , Sheibani, Vahid Kerman Neuroscience Research Center - Kerman University of Medical Sciences , Abbasi, Maryam Department of Medicinal Chemistry - Faculty of Pharmacy and Drug Design & Development Research Center - Tehran University of Medical Sciences , Firoozpour, Loghman Department of Medicinal Chemistry - Faculty of Pharmacy and Drug Design & Development Research Center - Tehran University of Medical Sciences , Tabatabai, Abbas Department of Medicinal Chemistry - Faculty of Pharmacy - Shaheed Beheshti University of Medical Sciences, Tehran , Shafiee, Abbas Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences , Foroumadi, Alireza Kerman Neuroscience Research Center - Kerman University of Medical Sciences - Pharmaceutical Sciences Research Center - Tehran University of Medical Sciences
Abstract :
Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED50 = 1.2 (0.5-1.9) mg/Kg]. Amongst the compounds tested, compound 3, 3-amino-5- [4-chloro-2-(2-flurophenoxy)phenyl]-4H-1,2,4-triazole, showed potent anticonvulsant activity [ED50 = 1.4 (1.0-2.2) mg/Kg] compared to diazepam
Keywords :
Synthesis , Triazole , Anticonvulsant , Benzodiazepine
Journal title :
Astroparticle Physics
